移植前鼻腔评估的重要性:通过元分析进行系统审查,并提出查协议
Casper De Vriese1, Constantijn Bogaert, Steven Van Laecke
1>From the Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Flemish Region, Belgium.
概括
移植前的鼻炎在干细胞移植患者中很常见. 建议对这些患者进行例行鼻评估和CT扫描,以评估风险.
科学领域:
- 移植医学 移植医学
- 传染病 传染病 传染病 传染病
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 免疫功能受损的移植接受者容易患上鼻炎.
- 目前的指导方针缺乏移植前的鼻评估协议.
研究的目的:
- 在移植患者中确定鼻炎的患病率和死亡率.
- 制定一个基于证据的移植前查协议.
主要方法:
- 27项研究的系统审查和元分析 (22项元分析).
- 在PubMed,Scopus和谷歌学者中进行了搜索.
- 使用GRADE系统评估偏差风险.
主要成果:
- 移植前鼻炎的患病率:在血造干细胞移植 (HSCT) 患者中为22.2%,在固体器官移植 (SOT) 患者中为3.9% (RR 4.9).
- 移植受体与或没有鼻炎之间没有总体死亡率差异.
- 移植前鼻炎的HSCT接受者死亡风险较高 (RR 2.8).
结论:
- 所有移植接受者都需要进行移植前的鼻评估.
- 由于患病率和死亡风险较高,建议在HSCT之前进行常规的鼻外腔CT.
- 提出了一项用于移植前鼻评估的查方案.
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