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Updated: Jun 21, 2025

An In-vitro Preparation of Isolated Enteric Neurons and Glia from the Myenteric Plexus of the Adult Mouse

An In-vitro Preparation of Isolated Enteric Neurons and Glia from the Myenteric Plexus of the Adult Mouse

Published on: August 7, 2013

人类和小鼠肠道神经系统中围神经网络的描述性研究

Matheus Deroco Veloso da Silva^1,2, Cristiano Correia Bacarin¹, Camila Cristina Alves Machado¹

¹Laboratory of Enteric Neuroscience, Department of Histology, State University of Londrina, Londrina, Paraná, Brazil.

Journal of neurochemistry

|July 6, 2024

概括

围神经网络 (PNN) 对于中枢神经系统中神经元功能至关重要,现在可以在肠道神经系统中找到. 它们在肠道中的存在和组成因物种而异.

科学领域:

神经科学是一个神经科学.
胃肠病学胃肠病学
细胞外矩阵生物学细胞外矩阵生物学

背景情况:

围神经网络 (PNN) 是专门的细胞外矩阵结构,是中枢神经系统 (CNS) 中神经元功能和保护不可或缺的组成部分.
从历史上看,PNN仅在中枢神经系统中被记录下来,而它们在肠道神经系统 (ENS) 的存在和作用仍未被探索.

研究的目的:

调查和确认肠道神经系统 (ENS) 中PNN的存在.
描述ENS中PNN的分子组成,并在物种之间进行比较.

主要方法:

分析小鼠和人类肠道组织样本.
利用RT-PCR和免疫光分析进行检测和鉴定.
作为标准PNN标志物和关键PNN相关蛋白家族的抗体使用了Wisteria floribunda聚素 (WFA).

主要成果:

在小鼠和人类的ENS中确认了PNN组件的存在.
确定ENS PNN的分子构成是特定于物种的.

结论:

在肠道神经系统中存在PNN,它们已知的分布范围超出了中枢神经系统.
在ENS中PNN的分子组成表现出特定物种的变异,表明独特的功能适应.

关键词:

细胞外矩阵是细胞外矩阵.在这里,我们可以看到子子.我们的肠道是肠道.神经元神经元是一个神经元.周神经神经网络

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