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精确量化十个甲基化纯素核化物通过高度敏感和稳定的同位素稀释的UHPLC-MS/MS

Lyuye Zhang1,2, Weibing Zhang1, Hailin Wang2,3,4

  • 1Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China.

Analytical chemistry
|July 6, 2024
PubMed
概括

一种新的UHPLC-ESI-MS/MS方法准确量化了12种细胞中的纯原核糖核酸,包括修饰形式. 这种技术增强了信号检测和分离异构体,有助于癌症生物标志物研究.

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相关概念视频

High-Resolution Mass Spectrometry (HRMS)01:15

High-Resolution Mass Spectrometry (HRMS)

The resolution of a mass spectrometer depends on the efficiency of separating ions with different ion masses. The mass of an atom is approximated to the sum of the masses of protons and neutrons inside, considering the masses of protons and neutrons as equal. However, the masses of the proton (1.6726 × 10−24 g) and neutron (1.6749 × 10−24 g) are not truly equal. There is a minor error in the expression of atomic masses relative to the simplest atom of hydrogen. For example, the mass of helium...