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新生儿光疗和风险-一项基于丹麦人口的研究

Yuelian Sun^1,2,3, Julie Werenberg Dreier^4,5, Chunsen Wu^6,7

¹Department of Neurology, Department of Clinical Medicine, Aarhus University Hospital, Affiliated Member of the European Reference Network EpiCARE, Aarhus, Denmark. ys@clin.au.dk.

European journal of pediatrics

|July 6, 2024

概括

新生儿黄的新生儿光疗不会增加患的风险. 这项研究发现光疗治疗与儿童之间没有关联,即使考虑了各种因素.

科学领域:

新生儿护理新生儿护理
儿科神经学儿科神经学
公共卫生公共卫生

背景情况:

新生儿高 bilirubinemia 是常见的,经常用光疗治疗.
一些研究表明,光疗与儿童之间存在潜在联系.
需要进一步的研究来澄清超白血症,光疗和风险之间的关系.

研究的目的:

评估暴露于新生儿光疗的儿童风险.
调查新生儿光疗与随后的诊断之间的关联.

主要方法:

在丹麦 (2002-2016) 出生的生育年龄≥35周的活生生的单身婴儿的队列研究.
考克斯回归模型被用来估计的危险比率 (HR).
调整HRs (aHR) 是使用多变量和倾向得分匹配计算的,考虑到母体和新生儿的因素,包括血清胆红素水平.

主要成果:

在65,365名儿童中,1.5%接受了新生儿光疗.
新生儿光疗与的风险增加没有关联 (aHR 0.95;95% CI:0.43-2.09).
在具有胆红素测量的亚群中,光疗也没有显示风险增加 (aHR 1.26;95% CI: 0.54-2.97).

结论:

新生儿光疗与的风险增加无关.
考虑到母体和新生儿因素,包括胆红素水平,这一发现是正确的.
这项研究为新生儿光疗对风险的安全性提供了保证.

关键词:

一群人群的队列.是一种病.多变量模型是多变量模型.新生儿高 bilirubinemia 的情况.新生儿光疗新生儿光疗倾向性得分匹配的匹配方法

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