诊断时的血清酸盐水平预测了在患有壮症的患者中长期出现下垂体病的风险
Nahali Haver1, Reut Halperin1,2,3, Yossi Bar-On1,4
1Tel Aviv University Faculty of Medicine, Tel Aviv, Israel.
概括
壮症患者血清酸盐水平升高表明疾病复发和侵入性瘤的风险更高. 这一发现突出了酸盐作为长期壮病结果的潜在标志物.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 生物化学 生化学
背景情况:
- 过多的生长激素 (GH) 分泌会显著影响矿物平衡和血清酸盐水平.
- 血清酸盐作为长期结局标志物的临床实用性仍然未被评估.
研究的目的:
- 为了研究血清酸盐基线水平和长期疾病结局在壮症患者之间的关联.
- 评估血清酸盐作为疾病持续性,复发性和垂体功能改变的预测标记.
主要方法:
- 对61名壮病患者的回顾性研究在三级中心进行了跟踪.
- 分析包括患者特征,内分泌/生化评估和瘤参数.
- 方法包括相关性分析和基线酸盐水平的多变量逻辑回归.
主要成果:
- 基线上的高酸性血与较大的腺瘤,更高的侵入性腺瘤率和较低的血清皮质醇水平有关.
- 基线酸盐与IGF-1正相关,与早晨皮质醇负相关.
- 酸盐水平与垂体轴参与相关,并独立预测疾病进展/复发和侵入性腺瘤风险.
结论:
- 治疗前血清酸盐水平升高与疾病持久性和壮症复发的风险增加有关.
- 基线酸盐水平也与壮病患者的垂体功能改变有关.
- 血清酸盐可以作为一种有价值的预测标志物,用于壮症的结果.
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