相关实验视频

Updated: Aug 16, 2026

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures

Published on: December 26, 2016

执行基于代谢途径的乳腺瘤亚型化协议

Mohammad Askandar Iqbal¹, Kirk Smith², Prithvi Singh³

¹Thumbay Research Institute for Precision Medicine, Gulf Medical University, Ajman, United Arab Emirates; College of Medicine, Gulf Medical University, Ajman, United Arab Emirates.

|July 6, 2024

概括

这项研究引入了一项协议,用于分析乳腺瘤代谢,以对患者进行分层. 它使用基因放松调节得分和机器学习来识别代谢亚型,用于个性化癌症护理.

科学领域:

在瘤学瘤学.
代谢学代谢学代谢学
生物信息学是一种生物信息学.

背景情况:

乳腺瘤表现出不同的代谢特征.
代谢变化对癌症进展至关重要.
患者分层可以指导向治疗.

研究的目的:

提出分析乳腺瘤全球代谢情景的协议.
为了实现基于新陈代谢的患者分层.
为了在乳腺瘤中识别不同的代谢亚型.

主要方法:

在90个代谢途径中分析了1454个代谢基因.
计算每个瘤样本的途径放松调节得分.
集群分析和机器学习用于子类型识别的应用.

主要成果:

一种将基因级代谢数据转化为通路级信息的方法.
在乳腺瘤中识别不同的代谢亚型.
为每个代谢亚型开发机器学习签名.

结论:

该协议促进了乳腺瘤代谢的全面分析.
代谢分析可以揭示不同的患者亚组.
这种方法支持开发基于代谢的治疗策略.

关键词:

癌症癌症癌症癌症癌症代谢代谢代谢代谢系统生物学系统生物学

更多相关视频

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers

Published on: December 5, 2017

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material

Published on: August 1, 2018

相关概念视频

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...