对检查点抑制剂诱导的大肠炎的一年后续研究:来自欧洲联盟的结果
M V Lenti1, D G Ribaldone2, F Borrelli de Andreis3
1Department of Internal Medicine and Medical Therapeutics, University of Pavia, Pavia, Italy; First Department of Internal Medicine, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
免疫检查点抑制剂 (ICI) 诱导的大肠炎的结果数据有限. 一项研究发现,12个月的临床缓解率为47.7%,微观结肠炎与更好的结果相关,而克罗恩氏病类型的模式表明缓解失败.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 诱导的结肠炎的临床结果尚未得到充分证实.
- 这项研究旨在描述患有ICI诱导性结肠炎的患者的12个月临床结果.
研究的目的:
- 评估ICI诱导大肠炎患者的12个月临床缓解率.
- 确定与实现或未能实现缓解相关的因素.
主要方法:
- 一项回顾性,欧洲的多中心研究,涉及确诊的ICI诱导性结肠炎患者.
- 评估了12个月的临床缓解 (CTCAE腹级0-1) 和分析了缓解的相关性.
主要成果:
- 包括96名患者;肺癌和黑色素瘤是最常见的相关癌症.
- 12个月的临床缓解率为47.7%. 类似克罗恩氏病的结肠炎模式与缓解失败有关 (HR 3.84).
- 微观性结肠炎和微观模式与UC/CD类结肠炎相比,与更好的结果有关. 暂停ICI并没有影响缓解.
结论:
- 患有炎症性肠病 (IBD) 类结肠炎的患者可能会从早期的,积极的治疗策略中受益.
- 需要进一步的研究,以提高ICI诱导性结肠炎的长期临床结果.
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