黑色素在辅助生殖中改善受精率:系统性审查和元分析
Eduardo Carvalho de Arruda Veiga1, Marise Samama2, Fabio Ikeda3
1GERA Instituto de Ensino e Pesquisa em Medicina Reprodutiva de, São Paulo, SP, Brazil; Department of Obstetrics and Gynecology, Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP), São Paulo, SP, Brazil.
Clinics (Sao Paulo, Brazil)
|July 6, 2024
概括
黑胺补充剂在辅助生殖中改善了受精率,但没有显著影响临床怀孕率. 这种激素显示出增强特定ART结果的前景.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 生物化学 生物化学
- 不孕症研究 不孕症研究
背景情况:
- 桃腺中的激素美拉托尼,具有显著的抗氧化特性.
- 它在生殖健康和辅助生殖技术 (ART) 中的潜在作用需要研究.
研究的目的:
- 系统地审查和元分析黑激素对ART结果的影响.
- 评估黑激素对关键生育指标和怀孕率的影响.
主要方法:
- 进行了过去15年发表的研究的系统审查和元分析.
- 搜索了包括PubMed在内的数据库;选出了17篇文章.
- 对照治疗组 (有黑激素) 与对照组 (没有黑激素) 的ART结果.
主要成果:
- 在临床怀孕率 (p = 0.64) 中没有观察到统计学意义上的差异.
- 在成熟卵细胞 (MII) (p = 0.001) 中, antral 毛囊数量 (p = 0.0002) 和受精率 (p ≤ 0.0001) 中发现了显著的改善.
结论:
- 黑色素对特定的ART参数具有有益影响,特别是改善受精率.
- 尽管对卵细胞成熟和受精有积极影响,但临床怀孕率没有达到统计学意义.
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