韩国减肥与心血管结果和死亡率之间的关联:一项全国性队列研究
So Yoon Kwon1, Gyuri Kim2, Seohyun Kim3
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Daegu Catholic University Hospital, Daegu Catholic University School of Medicine, Daegu, South Korea.
显著的体重减轻 (>3%) 会增加心血管疾病 (CVD) 的风险,包括死亡率. 然而,定期炼可以减轻这些不良影响,突出体力活动.
科学领域:
- 心血管健康 心血管健康
- 代谢健康 代谢健康
- 流行病学 流行病学
背景情况:
- 减肥已被认为可以减少心血管疾病 (CVD) 的发生率.
- 体重减轻和心血管疾病死亡率之间的关联受到辩论.
- 了解减肥对心血管疾病结果的影响至关重要.
研究的目的:
- 调查体重减轻与心血管疾病发病率之间的关联.
- 为了检查不同程度的减肥和心血管疾病风险之间的关系.
- 探索定期运动对心血管疾病死亡率的潜在修饰作用.
主要方法:
- 一项对韩国1020,533名年龄在40至80岁的成年人进行的回顾性队列研究.
- 数据收集了超过7.2年的数据,参与者在2年内至少进行了两次健康检查.
- 考克斯的比例危险模型用于分析体重减轻和心血管疾病发病率.
主要成果:
- 体重减轻>3%与结合心血管疾病事件的风险增加相关 (HR: 1.24-1.45).
- 体重减轻与非致命心血管疾病事件和心血管疾病死亡率的风险增加有关.
- 经常运动被发现可以减轻减肥对心血管疾病死亡率的不良影响.
结论:
- 体重减轻超过3%与心血管疾病事件风险增加有关.
- 定期体育活动可能会提供一种保护作用,防止在减肥后心血管疾病死亡率.
- 身体活动在减轻与减肥相关的心血管疾病风险方面的作用需要进一步研究.
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