沙特阿拉伯的降血糖剂的治疗修改模式:回顾性真实世界数据分析
Almaha Alfakhri1, Ohoud Almadani1, Turki Althunian2
1Saudi Food and Drug Authority, Riyadh, Saudi Arabia.
Diabetes research and clinical practice
|July 6, 2024
概括
在沙特阿拉伯,近一半的糖尿病患者经历了抗糖尿病治疗的修改或中断. 这些变化包括添加新的药物和单疗法和双疗法方案之间的切换.
科学领域:
- 药理学 药理学是指药理学的学科.
- 内分泌学 在内分泌学.
- 医疗保健服务研究 医疗服务研究
背景情况:
- 越来越多的抗糖尿病药物的可用性导致了不同的处方模式.
- 关于特别是在沙特阿拉伯的抗糖尿病药物修改模式的数据有限.
研究的目的:
- 描述沙特阿拉伯成年患者抗糖尿病药物修改和中断的模式.
- 提供关于该地区糖尿病管理不断变化的景观的见解.
主要方法:
- 对2016-2022年患者数据的回顾性分析,包括年龄在18岁以上,至少有一份抗糖尿病处方的个体.
- 评估两种修改类型:"补充" (引入新的抗糖尿病药物) 和"切换" (启动新的治疗情节).
- 用描述性统计数据分析患者特征和事件比例.
主要成果:
- 在122,291名被录取的患者中,近一半 (47.2%) 接受了治疗中断或修改,导致303,781次事件.
- 治疗中断是最常见的 (54%),其次是切换 (35%) 和附加疗法 (11%).
- 常见的补充模式包括二二酶-4 (DPP-4) 抑制剂,并观察到单疗法和双疗法方案之间的转变.
结论:
- 沙特糖尿病患者中很大一部分患者经历了治疗修改,突出显示了动态的治疗调整.
- 在单疗法和双疗法之间观察到的转变强调了糖尿病管理的复杂性.
- 这些发现对于未来的研究和在沙特阿拉伯糖尿病护理中的临床决策至关重要.
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