在单边的初级先天性玻璃眼中,进展到双边性
Aayush Majumdar1, Arnav Panigrahi1, Abhishek Singh1
1Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
概括
三分之一的患有单侧原发性先天性玻璃眼 (PCG) 患者经历了同伴眼睛的进展,通常在五年后. 在同伴眼中较大的角膜直径是这种进展的重要预测因素.
科学领域:
- 眼科医生 眼科 眼科
- 玻璃眼研究研究 玻璃眼研究
- 儿科眼科医生 儿科眼科医生
背景情况:
- 初级先天性玻璃眼 (PCG) 是一种罕见的,严重的玻璃眼形式,在出生时出现.
- 单边PCG需要对未受影响的同伴眼睛进行仔细监测,以发现潜在的疾病发展.
- 在单边PCG中,对同伴眼睛进展的长期结果和风险因素尚未完全理解.
研究的目的:
- 为了确定单边PCG患者同眼中的眼内压力 (IOP) 升高的发生率.
- 在延长的随访期间识别与同伴眼睛进展相关的风险因素.
主要方法:
- 对单边PCG患者的医疗记录的回顾性审查,至少有5年的随访.
- 通过视神经缩增加或升高的IOP (>21 mm Hg) 定义的同眼进展的分析.
- 风险因素的评估包括IOP,视敏度,轴长,中角膜厚度,角膜直径和前段OCT发现.
主要成果:
- 32% (17/54) 的同眼患者在平均8.2年后发展为眼高血压或青光眼.
- 在随访时,角膜直径大 (>12毫米) 的眼睛具有显著更高的进展可能性 (OR = 9.5,P = 0.01).
- 在进步的同眼中更频繁地观察到一种明显的上眼道 (OR = 1.4).
结论:
- 在单边PCG病例中,显著比例的未受影响的眼睛会发展为渐进性疾病.
- 随访时的角膜直径是其他眼睛进展的强有力的预测因素.
- 早期检测和监测对于管理PCG中潜在的双边疾病至关重要.
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