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用于结肠直肠癌治疗的伊利诺特干载磁石-芯外系统

Cristina Chircov¹, Mihai-Cătălin Petcu², Bogdan Stefan Vasile³

¹Department of Science and Engineering of Oxide Materials and Nanomaterials, National University of Science and Technology Politehnica Bucharest, 011061 Bucharest, Romania; National Research Center for Micro and Nanomaterials, National University of Science and Technology Politehnica Bucharest, 060042 Bucharest, Romania.

International journal of pharmaceutics

|July 6, 2024

概括

研究人员为结直肠癌治疗开发了含有虹膜素的磁石-芯外系统. 这些纳米结构系统显示针对癌细胞的有效性,为传统疗法提供了有希望的替代方案.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
生物医学工程生物医学工程

背景情况:

结肠直肠癌是全球癌症相关死亡的主要原因之一.
像手术和化疗这样的传统治疗方法在有效性上有局限性.
需要先进的药物输送系统来控制化学疗法剂的释放.

研究的目的:

开发和评估含有伊利诺特坎的磁石-芯外纳米颗粒.
评估这些纳米载体的物理化学,形态结构和生物特性.
研究它们作为结直肠癌的向药物递送系统的潜力.

主要方法:

通过溶热和斯托伯方法合成磁石-芯-外纳米颗粒.
使用XRD,HR-TEM (与HAADF),FT-IR,TG-DSC,UV-Vis光谱光度和BET分析进行表征.
使用MTT测定对正常和癌细胞系的生物功能评估.

主要成果:

形成具有高晶性磁铁岩核与半孔性二氧化外 (2-7 nm) 的磁铁岩核.
药物加载和释放动力学受到合成的影响,CTAB缺少产生更高的负载和更低的释放.
纳米结构系统对HT-29结肠直肠腺癌细胞表现出有针对性的疗效,不影响正常的L929细胞.

结论:

这项研究成功地开发了载核纳米载体,用于潜在的癌症治疗.
结果突出了这些系统可调节的药物加载和释放特性.
证明的向细胞毒性为改善结直肠癌治疗提供了一个有希望的途径.

关键词:

癌症治疗治疗癌症治疗核心外系统核心外系统氨酸是一种氨酸.磁铁石是一种磁铁石.石是什么意思石是什么意思

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