产前压力影响胎儿的神经发育:妊娠脆弱性的时间窗口
James M Collins1, James M Keane2, Clara Deady1
1APC Microbiome Ireland, University College Cork, Cork, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
Neuroscience and biobehavioral reviews
|July 6, 2024
概括
产前压力会影响后代的神经发育,时机至关重要. 识别脆弱性的关键窗口是理解和减轻精神病理学风险的关键.
科学领域:
- 神经发育科学 神经发育科学
- 精神病学是一个精神病学.
- 发展心理学是发展心理学.
背景情况:
- 产前母亲的压力,从日常麻烦到创伤,会对后代的神经发育产生不利影响.
- 产前应激暴露的时间显著影响神经发育结果和精神病理风险.
研究的目的:
- 审查关于运动,认知,语言和行为发展的临界产前应激暴露窗口的经验证据.
- 探索介导产前压力对神经发育影响的机制.
- 确定研究缺口和未来方向.
主要方法:
- 对关于产前压力和神经发育的人类和动物研究的系统审查.
- 对介导机制的分析,包括下丘脑-垂体-上腺轴,血清激素和免疫功能.
- 评估跨发育领域的时间漏洞窗口.
主要成果:
- 对于特定的精神病理结果,存在广泛的发展窗口.
- 对复杂的认知和行为结果的不一致性.
- 多种生物机制调解压力影响,包括HPA轴,血清素,胎盘,免疫和肠道微生物群的改变.
结论:
- 产前压力的时间对神经发育结果至关重要.
- 需要进一步的研究,以确定精确的脆弱期,使用分子标记.
- 识别特定的生物分子特征对于有针对性的干预措施至关重要.
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