食物过敏,治疗和耐受性中的状细胞
Elise G Liu1, Xiangyun Yin2, Emily R Siniscalco3
1Section of Rheumatology, Allergy and Immunology, Department of Medicine, Yale University School of Medicine, New Haven, Conn.
The Journal of allergy and clinical immunology
|July 6, 2024
概括
了解树突细胞 (DCs) 是开发食物过敏治疗的关键. 肠道和皮肤中的这些细胞可以促进耐受性或引发过敏,从而影响免疫疗法反应.
科学领域:
- 免疫学 免疫学 免疫学
- 过敏研究 研究过敏
- 细胞生物学 细胞生物学
背景情况:
- 食物过敏是一种严重的健康问题,几乎没有有效的治疗方法.
- 树突细胞 (DCs) 是一种抗原呈现细胞 (APC),对于调节免疫反应至关重要,包括口服耐受性和食物过敏.
- 肠道和皮肤中的不同的DC子集具有独特的功能,影响免疫结果.
研究的目的:
- 阐明树突细胞 (DCs) 中介食物耐受性和过敏的机制.
- 探索DCs在各种食品免疫疗法模式中的作用.
- 确定将APC引导到一个耐受性计划的策略.
主要方法:
- 基于表面标记物和功能,对肠道和皮肤中的树突细胞 (DC) 子集进行分析.
- 研究RORγt+ APCs在诱导外围调节性T细胞以获得口服耐受性的作用.
- 检查在炎症条件下DC激活 (例如,警报剂释放,肠道失调) 和它们在过敏敏感化中的作用.
- 评估Langerhans细胞在表皮皮质免疫治疗反应中的必要性.
主要成果:
- 肠道DC和RORγt+ APC对于通过调节性T细胞诱导口服耐受性至关重要.
- 皮肤,肠道和肺部的DC可以促进过敏敏感性,当被炎症刺激激活时,如警报剂释放或肠道失调.
- 皮肤中的朗格汉斯细胞对于皮肤上免疫疗法的有效性至关重要.
结论:
- 树突细胞在食物过敏中起着双重作用,根据环境和激活刺激,促进耐受性或敏感性.
- 准DC功能和了解它们的激活途径对于开发新型食物过敏疗法和改善免疫治疗至关重要.
- 需要进一步的研究,以确定激活过敏激发DC的现实世界刺激,并开发用于选择性诱导APC中的耐受性程序的方法.
相关概念视频
01:20Special Features of Adaptive Immunity
794
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
794
02:06Allergic Reactions
27.3K
Overview
27.3K
01:30Hypersensitivities
579
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
579
01:24T Cell Types and Functions
996
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
996
01:40Cell-mediated Immune Responses
68.0K
Overview
68.0K
01:22Antigen Presenting Cells
1.7K
The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
1.7K