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Updated: Jun 21, 2025

Crystallizing Membrane Proteins for Structure Determination using Lipidic Mesophases
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Crystallizing Membrane Proteins for Structure Determination using Lipidic Mesophases

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用低温电子显微镜研究的模型脂质膜中的相分离

Frederick A Heberle1, M Neal Waxham2

  • 1Department of Chemistry, University of Tennessee, Knoxville, TN, United States.

Methods in enzymology
|July 6, 2024
PubMed
概括

低温电子显微镜 (cryo-EM) 可视化单个脂质体,在没有外部探针的情况下揭示膜异质性. 这种方法通过分析有序和无序的膜阶段的厚度和密度变化来增强对脂质结构的理解.

关键词:
双层结构是双层结构.脂质艇是一种脂质艇.流动性失调的流动性失调的情况有流动性订单的流动性订单.纳米领域是纳米领域.

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Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
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