老年人口腔功能下降和唾液生物标志物之间的关系:一个横截面研究
Kenji Masutomi1, Mika Bando2, Yuji Inagaki1
1Department of Periodontology and Endodontology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-Cho, Tokushima, 770-8504, Japan.
BMC oral health
|July 6, 2024
概括
唾液生物标志物如calprotectin,8-OHdG和AGE与老年人口腔功能下降有关. 这一发现可能有助于在老年人群中早期发现和管理口腔健康下降.
科学领域:
- 老年学是指老年学的学科.
- 口腔健康 口腔健康
- 生物标志物研究 生物标志物研究
背景情况:
- 老年人口腔健康问题正在增加,口腔功能下降是一种复杂的疾病.
- 口腔功能下降包括七个关键的迹象和症状,包括口腔卫生不良,干燥,力减少,舌头/唇部运动受损.
- 唾液生物标志物在评估口腔和全身疾病方面表现有前途,使其成为老年人健康监测的有价值工具.
研究的目的:
- 调查老年人口腔功能下降和唾液生物标志物水平之间的关联.
- 为了确定特定的生物标志物是否可以表明口腔功能下降的存在或严重程度.
主要方法:
- 一项横截面研究包括了116名65岁及以上的参与者.
- 如果符合7个测试标准中的3个或以上,则诊断出口腔功能低下.
- 唾液生物标志物水平使用酶相关的免疫吸收试验量化.
主要成果:
- 很大一部分 (63.8%) 的参与者被诊断出口腔功能下降.
- 卡尔蛋白蛋白水平与口腔水分和功能相关.
- 8-OHdG和AGE水平与舌头/唇部运动功能和口腔卫生有关.
结论:
- 唾液calprotectin,8-OHdG和AGE水平与老年人的口腔功能下降有显著的关联.
- 这些生物标志物可以作为口腔功能下降的指标,有助于早期检测和干预策略.
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