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Updated: May 3, 2026

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由一组后突触蛋白形成的模拟复合体表明,低形态的Shank突变具有局部效应

Marcell Miski1, Áron Weber1,2, Krisztina Fekete-Molnár1

  • 1Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, Hungary.

BMC neuroscience
|July 6, 2024
PubMed
概括

了解突变如何影响后突触密度 (PSD) 对学习和记忆研究至关重要. 我们的建模表明,突变效应取决于整体蛋白质的可用性,而不仅仅是单个蛋白质水平.

关键词:
结合性亲缘关系是一种结合性亲缘关系.吉尔斯皮算法 吉尔斯皮算法突变突变是一种突变.后突触密度是指突触后的密度.蛋白质复合体是一种蛋白质复合体.蛋白互动网络是蛋白互动网络.蛋白质:蛋白质相互作用系统生物学 系统生物学

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Assembly of Signaling Complexes01:30

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Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
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