与脂肪肝疾病相关的周边乳牛的血清大元素和微元素水平
Ke-Xin Zhang1,2,3, Ke Li1,2,3, Zhe-Hao Li1,2,3
1College of Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Tai'an City, Shandong Province, 271018, China.
BMC veterinary research
|July 6, 2024
概括
血清矿物质水平可以帮助诊断乳牛脂肪肝. 具体的矿物质,如和,当测量7天后,可以作为这个代谢疾病的早期预警指标.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 动物科学动物科学
- 代谢疾病 代谢疾病
背景情况:
- 乳牛的脂肪肝是一种普遍的代谢障碍,其特点是肝细胞中三糖的积累.
- 目前的诊断方法,如肝活检是侵入性的,对乳制品行业经济不利.
- 需要有效的,非侵入性的诊断工具,以早期检测脂肪肝.
研究的目的:
- 探索血清生物标志物的潜力,以诊断和提供乳牛脂肪肝早期预警.
- 在血液中识别与脂肪肝存在相关的特定宏观元素和微观元素.
主要方法:
- 从24头哺乳母牛收集血清样本,根据肝活检分为健康肝脏和脂肪肝组 (每组n=12个).
- 诱导合等离子体质谱法 (ICP-MS) 用于量化宏元素和微元素度.
- 多变量分析,包括变量重要性预测和ROC曲线分析,用于确定诊断指标.
主要成果:
- (Ca), (K), (Mg), (Sr), (Se), (Mn), (B) 和 (Mo) 的血清度在脂肪肝的奶牛中比健康奶牛低.
- 相反,具有脂肪肝的奶牛的铜 (Cu) 含量更高.
- 健康和脂肪肝牛之间的矿物质含量最显著的差异是在分娩后7天观察到的.
结论:
- 有脂肪肝的奶牛的Ca,K,Mg,Se,B,Mo,Mn和Sr的血清水平发生了显著的变化.
- 产后7天的时间是使用这些生物标志物的最佳时间来早期识别脂肪肝.
- (Ca), (Se), (K), (B) 和 (Mo) 被确定为产后奶牛脂肪肝最有效的诊断指标.
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