基因组测序揭示了两个芽的酵母物种在实验进化期间的融合适应
Pu Wang1,2, William W Driscoll3,4, Michael Travisano3,5
1Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN, 55455, USA. wang5922@umn.edu.
Communications biology
|July 6, 2024
概括
融合进化推动了多细胞性. 在酵母菌中,像ACE2这样的常见基因驱动这种特征,尽管有数百万年的分歧,但显示出共同的机制.
科学领域:
- 进化生物学是进化的生物学.
- 微生物学 微生物学
- 遗传学 遗传学 是一个
背景情况:
- 融合进化是理解多细胞性起源的关键.
- 研究融合的多细胞进化是复杂的,因为不同的进化路径和环境.
研究的目的:
- 为了确定酵母细胞融合多细胞进化的遗传基础.
- 为了比较不同的酵母物种,Kluyveromyces lactis和Saccharomyces cerevisiae之间的融合进化.
主要方法:
- 哈普洛伊德酵母种群 (K. lactis) 进行了选择,以增加在液体介质中的沉积.
- 进行了基因组和表型分析以确定遗传变化.
- 鉴定了赋予多细胞性的基因突变,并在物种之间进行了比较.
主要成果:
- 通过ACE2或AIM44的突变,K. lactis进化了多细胞性,其中ACE2是主要的驱动因素.
- 这些基因是之前在S. cerevisiae多细胞性中发现的基因的一个子集.
- 无论是ACE2还是AIM44,都调节细胞分裂,这表明保留的机制是基因融合的基础.
- 在K. lactis系中观察到具有多个ACE2/AIM44基因型的复杂种群动态.
结论:
- 多细胞性中的融合进化是由共同的祖先和自然选择所塑造的.
- 保存的细胞复制机制可能解释了观察到的遗传融合.
- 融合进化中的分歧程度受到机会和偶然性的影响.
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