在接受手动基本生命支持的狗中,连续配对的动脉和关静脉治疗点值
Sabrina N Hoehne1, Kate Hopper2, Marlis L Rezende3
1Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA.
概括
在狗基本生命支持 (BLS) 期间采集动脉和静脉血液样本显示,随着时间的推移,治疗点 (POC) 变量的差异具有统计学意义,但不具有临床意义. 静脉采样可能是心肺复苏 (CPR) 期间动脉采样的实际替代方案.
科学领域:
- 比较生理学比较生理学
- 兽医重症监护服务 兽医重症监护服务
- 护理点诊断的诊断方法
背景情况:
- 准确的护理点 (POC) 测试对于指导基本生命支持 (BLS) 和心肺复苏 (CPR) 期间的治疗至关重要.
- 动脉血液采样具有侵入性和技术挑战性,特别是在紧急情况下.
- 了解动脉和静脉血液气体和电解质值之间的差异对于解释重病动物的POC结果至关重要.
研究的目的:
- 为了比较从手动BLS接受狗的动脉和关静脉血液样本中获得的治疗点 (POC) 变量.
- 在BLS期间评估这些POC变量随时间变化的变化.
- 确定观察到的动脉静脉差异和POC参数的时间变化的临床相关性.
主要方法:
- 实验研究涉及24只专门养的研究狗在一个小型动物研究设施.
- 在安乐死之前,狗接受了麻醉和动脉导管治疗.
- 手动BLS,包括胸部压缩和通风,是在心肺停止1分钟后开始的. 为POC测试,在基线 (T0),3分钟 (T3) 和6分钟 (T6) 时采集了双对动脉和关静脉血液样本.
主要成果:
- 与静脉样本相比,动脉样本显示Pao2,离子间隙,,化物,葡萄糖和PCV显著更高 (P < 0.03).
- 经过6分钟的BLS,观察到葡萄糖,过量,静脉pH,乳酸盐,,肌,碳酸盐和的显著增加.
- 从基线的动脉和静脉样本中,Pao2,电离,PCV和血总蛋白的显著下降 (P <0.05).
结论:
- 虽然在统计学上显著,但在BLS期间的动脉静脉差异和POC变量的时间变化很小,并且不具有临床意义.
- 鉴于与动脉采样相关的困难,静脉血液采样可能是CPR期间可行的替代方案.
- 需要进一步的研究来探索POC测试在狗的高级生命支持期间的作用.
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