有机酸暴露与全因和因特定死亡率之间的关联:一项基于全国人口的队列研究
Panpan Gao1, Pengxi Wang2, Xiaoan Zhang3
1Department of Clinical Nutrition, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
概括
有机酸 (OPE) 暴露与所有死因和心血管疾病的死亡风险更高有关. 减少OPE暴露可能会降低死亡负担并改善公共卫生结果.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 流行病学 流行病学
背景情况:
- 有机酸 (OPE) 是广泛使用的化学物质,与慢性疾病有关.
- 在OPE暴露和死亡风险之间的关联仍然不完全理解.
- 尿中的OPE代谢物作为人类暴露评估的生物标志物.
研究的目的:
- 研究尿路OPE代谢物与死亡风险之间的关系.
- 评估特定OPE与所有原因和特定原因死亡率的关联.
- 为减轻OPE相关健康风险的公共卫生战略提供信息.
主要方法:
- 利用了来自国家健康和营养检查调查 (2011-2018) 的数据.
- 包括6,869名成年参与者 (≥18岁) 死亡率随访至2019年12月31日.
- 采用多变量COX回归来分析危险比率 (HR) 和95%置信区间 (CI).
主要成果:
- 在平均5.0年的随访期间,发生了406例死亡.
- 2-乙烯酸盐暴露与所有原因死亡率的增加显著相关 (HR: 1.12; 95% CI: 1.05-1.20).
- 2-乙烯酸盐暴露也与较高的心血管死亡率有关 (HR: 1.15; 95% CI: 1.04-1.26).
结论:
- 对OPE的暴露与所有原因和心血管死亡率的风险增加有显著的关联.
- 特定的OPE代谢物,如2-乙烯酸盐,可能表明死亡风险增加.
- 控制环境OPE暴露对于减少公众健康死亡负担至关重要.
相关概念视频
Anticholinesterase Agents: Poisoning and Treatment
837
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
837
Types of Toxins
1.7K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.7K
Toxic Reactions: Overview
964
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
964
Effects of Chemicals: Overview
1.2K
Drugs, encompassing various chemical compounds from natural sources, lab synthesis, or genetic engineering, elicit different biological responses in living organisms. Some of these responses are desirable or therapeutic, while others are undesirable. The primary goal of administering a drug is to achieve a therapeutic effect, that is, to address a specific disease or health condition. Any concurrent effects outside of this therapeutic outcome are considered undesirable. These undesirable...
1.2K
Analysis of Population Pharmacokinetic Data
252
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
252
The Periodic Table and Organismal Elements
177.8K
Overview
177.8K


