增强癌细胞增殖和具有高BRCA1基因表达率的乳腺癌中的侵略性表型平衡
Kohei Chida1,2, Masanori Oshi1,3, Arya Mariam Roy4
1Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Elm & Carlton Streets, Buffalo, NY, 14263, USA.
乳腺癌 (BC) 的高BRCA1基因表达与增加的增殖和侵略性瘤表型相关. 然而,这种高度表达不会影响患者的生存结果.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 虽然BRCA1突变已得到充分研究,但BRCA1基因表达在乳腺癌 (BC) 的临床意义仍未得到充分研究.
- 在癌细胞增殖过程中,DNA修复机制至关重要,这表明BRCA1表达和瘤攻击性之间存在潜在联系.
研究的目的:
- 为了研究高BRCA1基因表达和乳腺癌中的侵袭性瘤生物学之间的关联.
- 确定BRCA1基因表达水平是否与乳腺癌患者的临床结果相关.
主要方法:
- 分析了来自三大队伍的基因表达数据:癌症基因组图谱 (TCGA),METABRIC和SCAN-B,共计6245名乳腺癌患者.
- 对BRCA1表达与瘤特征的相关性分析,包括组织学等级,增殖得分和免疫细胞透.
主要成果:
- 没有BRCA1突变的乳腺癌患者表现出与DNA修复功能相关的更高的BRCA1表达.
- 高的BRCA1表达与增加的癌细胞增殖,同源重组缺陷和内异质性有关.
- 尽管与增殖和攻击性表型有联系,但BRCA1表达与乳腺癌患者在亚型中的存活率没有相关性.
结论:
- 乳腺癌中的高BRCA1基因表达与增加的增殖和潜在的侵略性瘤表型有关.
- 与BRCA1突变不同,BRCA1基因表达水平似乎不是乳腺癌患者生存的预后标记.
更多相关视频
08:53Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
Published on: February 17, 2011
11:47Time-lapse Imaging of Primary Preneoplastic Mammary Epithelial Cells Derived from Genetically Engineered Mouse Models of Breast Cancer
Published on: February 8, 2013
相关概念视频
Abnormal Proliferation
Targeted Cancer Therapies
There are several types of targeted therapies against...
Cancer-Critical Genes I: Proto-oncogenes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Cancer
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
