控制的卵巢刺激会导致体外受精患者的心血管变化
Laura Sarno1, Ida Strina2, Paola Borrelli3
1Department of Neurosciences, Reproductive Science and Dentistry, University Federico II, Via Pansini 5, 80131 Naples, Italy.
概括
在接受体外受精的妇女中,受控的卵巢刺激会导致母亲的显著心血管变化. 这些血液动力学变化在刺激周期中迅速发生,影响心脏输出量和中风体积指数.
科学领域:
- 生殖内分泌学和不孕不育问题
- 心血管生理学心血管生理学
- 医疗技术评估 医疗技术评估
背景情况:
- 控制性卵巢刺激 (COS) 是体外受精 (IVF) 的基石.
- 了解COS期间的血液动力学变化对于患者的安全和优化结果至关重要.
- 对抗剂协议通常用于COS,但其对母亲血液动力学的影响需要进一步调查.
研究的目的:
- 通过使用激素释放激素 (GnRH) 抗剂协议,研究接受COS的女性的动态血液动力学变化.
- 在刺激周期的不同阶段评估心血管参数,从基线到胚胎移植.
主要方法:
- 一项前性观察队列研究,涉及68名不育妇女,接受GNRH抗剂协议和新鲜胚胎移植的COS.
- 血液动力学参数,包括心脏输出 (CO),中风体积指数 (SVI) 和全身血管阻力指数 (RSVI),在基线,雌激素峰值和胚胎移植日使用超声波心脏输出监测器进行测量.
- 统计分析包括学生T测试和ANOVA来比较跨时间点和组之间的参数.
主要成果:
- 在COS期间观察到CO,SVI和RSVI的显著变化 (p < 0.05).
- 在hCG阳性和hCG阴性组之间没有发现血液动力学趋势的显著差异.
- 患有卵巢过度刺激综合征 (OHSS) 风险增加的患者显示SVI显著增加 (p = 0.010).
结论:
- 使用GnRH抗剂协议进行受控的卵巢刺激会导致母亲心血管参数发生显著,快速的变化.
- 这些发现强调了在COS期间监测血液动力学状况的重要性.
- 进一步的研究可能会探索这些血液动力学转移在试管婴儿患者的临床影响.
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