脂肪性肝病和艾滋病毒:2030年议程
Juan M Pericàs1, Anish K Arora2, Carlotta Riebensahm3
1Liver Unit, Vall d'Hebron University Hospital, Vall d'Hebron Institute for Research, Universitat Autònoma de Barcelona, Spanish Network of Biomedical Research on Liver and Digestive Diseases, Barcelona, Spain.
The lancet. HIV
|July 7, 2024
概括
艾滋病毒感染者面临脂肪肝疾病 (SLD) 的更高风险,但缺乏研究. 解决社会决定因素和优先考虑护理对于这种艾滋病毒和SLD综合征至关重要.
科学领域:
- 公共卫生 公共卫生
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
背景情况:
- 艾滋病毒感染者 (PLWH) 对代谢功能障碍相关的脂肪性肝病 (MASLD) 和其他形式的SLD的易感性增加.
- 从历史上看,PLWH一直被排除在SLD临床试验之外,导致对这种人群的风险因素和自然史的理解不佳.
- 在SLD流行病学和医疗保健障碍的知识差距,如耻辱妨碍有效管理艾滋病毒和SLD综合症.
研究的目的:
- 提供关于PLWH中SLD管理的全面视角.
- 检查健康的社会决定因素在肝病和代谢综合征并发症中的作用.
- 突出紧急需求并推研究,以解决PLWH中的数据缺口和保护肝脏健康.
主要方法:
- 这种观点综合了现有的文献和专家意见.
- 它检查了艾滋病毒,SLD和健康的社会决定因素的交叉.
- 建议是基于已识别的知识差距和临床需求.
主要成果:
- SLD是PLWH的一个重大问题,由健康的社会决定因素加剧.
- 在这个人群中,有必要进行包容性研究和改善SLD的医疗保健.
- 在艾滋病毒治疗中优先考虑SLD管理是必不可少的.
结论:
- 解决PLWH中SLD综合症需要采取多方面的方法,包括研究,政策变化和脱而出.
- 将SLD护理整合到常规HIV管理中至关重要.
- 迫切需要进一步的研究来填补流行病学和临床数据的空白.
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