在儿科前期治疗中比较内用德克斯梅德托米丁和胺:一项随机 randomised 研究
N Kumari1, P K Dubey1, S Singh1
1Department of Anaesthesiology, Indira Gandhi Institute of Medical Sciences, Patna, India.
Revista espanola de anestesiologia y reanimacion
|July 7, 2024
概括
内胺 (5毫克/千克) 在儿科前期治疗中比内的德克斯梅德托米丁 (1毫克/千克) 更有效,减少焦虑并改善麻醉诱导. 这项研究评估了2-10岁儿童的面部,腿部,活动,哭声和安慰度 (FLACC) 评分.
科学领域:
- 儿科麻醉学 儿科麻醉学
- 药理学 药理学是指药理学的学科.
- 疼痛管理 疼痛管理
背景情况:
- 儿科患者的前期治疗对于减少手术前的焦虑,确保顺利的诱导和预防术后的行为变化至关重要.
- 为了有效的前期治疗,儿童友好的施用方法是可取的.
研究的目的:
- 为了比较内用德克斯梅德托米丁和凯胺在接受全身麻醉的儿科患者中作为前期治疗的疗效.
- 为了评估面部,腿部,活动,哭声和安慰度 (FLACC) 在静脉注射过程中的评分.
主要方法:
- 一个前性,双盲,随机对照试验,涉及100名儿科患者 (2-10岁) 的ASA身体状况1和2.
- 患者接受了内德克斯梅德托米丁 (1毫克/公斤) 或内胺 (5毫克/公斤).
- 使用经过修改的耶鲁手术前焦虑量表简式 (mYPAS-SF) 评估了预药性焦虑,并通过FLACC量表测量了针插入的反应.
主要成果:
- 鼻内胺基因组的FLACC得分明显低于鼻内胺基因组的FLACC得分 (p=0.001).
- 在德克斯梅德托米丁组中,平均心率显著降低 (p=0.001).
- 在接受胺的患者中,有8%的患者出现了不良事件.
结论:
- 鼻内胺 (5毫克/千克) 在临床上比鼻内德克斯梅德托米丁 (1毫克/千克) 在2-10岁儿童的前期治疗中更有效.
- 胺在治疗手术前焦虑和促进麻醉诱导方面表现出较高的疗效,与通过鼻内途的德克斯梅德托米丁相比.
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