产前暴露于环境污染物和儿童神经发育结果之间的可能关联
Elena Berezovsky1, Elkana Kohn2, Malka Britzi3
1Pediatrics Division, Shamir (Assaf Harofeh) Medical Center, Zerifin, affiliated to the Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Reproductive toxicology (Elmsford, N.Y.)
|July 7, 2024
概括
产前暴露在塑料中发现的化学物质 - - 酸盐 - - 可能会对男孩的神经发育产生负面影响,影响认知和运动技能. 儿童暴露和PCB没有显著的发育关联.
科学领域:
- 环境健康 环境健康
- 发育儿科 发育儿科
- 毒理学 毒理学 毒理学
背景情况:
- 孕前暴露于环境化学物质,如酸盐和多双 (PCB) 是一个越来越令人担忧的问题.
- 了解这些暴露对儿童发育的影响对于公共卫生至关重要.
- 以前的研究表明,内分泌干扰化学物质与神经发育结果之间存在潜在的联系.
研究的目的:
- 调查产前和儿童期甲酸盐暴露和产前PCB暴露与4岁儿童神经发育之间的关联.
- 评估与特定化学物质暴露有关的认知,运动和感官发展.
- 确定这些关联中的潜在的性别特异性差异.
主要方法:
- 在分娩时的母亲和4岁儿童中测量尿甲酸代谢物.
- 测量了母体PCB的血清度.
- 使用韦克斯勒学前和小学智力尺度 (WPPSI-III),发育协调障碍问卷 (DCDQ) 和短感官概况 (SSP) 评估儿童的发展.
主要成果:
- 较高的母体尿甲酸代谢物水平与男孩的认知分数 (WPPSI-III) 相反相关,但在女孩中没有.
- 具体来说,更高的单基甲酸盐 (MBzP) 水平与男孩的认知,运动和感官评估得分较低相关.
- 儿童尿甲代谢物或母亲PCB水平与儿童发育结果之间没有发现显著的关联.
结论:
- 产前暴露于某些酸盐的较高水平,特别是MBzP,可能与年幼男孩的神经发育缺陷有关.
- 这些发现凸显了男性神经发育对特定产前化学物质暴露的潜在脆弱性.
- 需要进一步的研究来证实这些关联并探索潜在的机制.
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