自发脑内出血患者的脑内压力监测:系统性综述与元分析
Shanshan Duan1, Qiang Yuan2, Meihua Wang1
1Department of ICU of Hongqiao Campus, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
World neurosurgery
|July 7, 2024
概括
内压力监测可能会降低自发性脑内出血 (ICH) 的选定患者的死亡率,特别是那些没有心室内出血的患者. 然而,它并不能改善长期的神经功能结果,因此需要进一步研究以进行最佳的患者选择.
科学领域:
- 神经外科 神经外科
- 神经学 神经学
- 关键护理医学 关键护理医学
背景情况:
- 自发性脑内出血 (ICH) 的死亡率很高.
- 升高的内压力 (ICP) 是ICH患者不良结果的重要预测因素.
- 持续ICP监测在改善患者结果中的作用仍然是调查的主题.
研究的目的:
- 评估内压监测 (ICPM) 对自发性ICH患者的死亡率和功能结果的影响.
- 确定可能从ICPM中受益的ICH患者的潜在子组.
主要方法:
- 研究的系统审查和元分析,涉及自发性ICH患者,接受ICPM或不接受ICPM治疗.
- 主要结局包括住院和6个月死亡率.
- 二级结局是6个月的神经功能结局.
主要成果:
- 虽然ICPM显示出减少住院死亡率的趋势,但整体而言,这一趋势在统计学上并不显著.
- 除了心室内出血病例,ICPM显著降低了住院死亡率.
- 使用ICPM观察到6个月死亡率显著降低,特别是在没有腹腔内出血的患者中.
- 在ICPM和没有ICPM组之间没有发现6个月功能结果的显著差异.
- 升高的ICP与增加的死亡率和较差的功能结果密切相关.
结论:
- 升高的ICP与增加的死亡率和ICH中更差的预后有关.
- 在特定的ICH亚组中,ICP监测可能会提供生存益处,但不会增强神经功能.
- 需要进行进一步的研究,以确定用于ICP监测的最佳患者群体.
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