维生素和脂肪酸对抗化疗引起的肠粘膜炎
Alexandra Alcorta1, Laura López-Gómez2, Raffaele Capasso3
1Department of Basic Health Sciences, Faculty of Health Sciences, University Rey Juan Carlos (URJC), 28922 Alcorcón, Spain.
维生素和脂肪酸等营养药物在预防和治疗化疗引起的肠粘膜炎方面显示出有前途. 对饮食和营养的进一步研究可以改善癌症患者的护理,并减少不良影响.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 营养科学 营养科学
背景情况:
- 化疗可以改善癌症的生存率,但会导致严重的副作用.
- 肠道粘膜炎是抗瘤药物的常见和使人虚弱的胃肠道副作用.
- 粘膜炎可能导致疼痛,腹,厌食症,减肥,感染和死亡.
研究的目的:
- 审查营养药在治疗化疗引起的肠粘膜炎中的作用.
- 探索维生素,脂肪酸和基于脂质的产品在预防和缓解粘膜炎方面的潜力.
主要方法:
- 临床前 (细胞培养,动物模型) 和人类研究的叙述性综述.
- 对特定维生素 (A,D,E,B2,B9,C) 和脂肪酸 (欧米茄-3,CLA,短链,中链) 的研究分析.
- 对基于脂质的产品,如母油,橄油和脂质替代疗法的研究评估.
主要成果:
- 维生素,omega-3长链脂肪酸 (EPA,DHA,CLA),短链脂肪酸 (丁酸盐),中链脂肪酸 (酸) 和基于脂质的产品都显示出有益的影响.
- 这些营养药物显示出预防和缓解化疗引起的肠粘膜炎的潜力.
- 研究表明,富含有益脂肪酸和抗氧化剂的产品是有效的.
结论:
- 营养药物,包括各种维生素和脂肪酸,对化疗引起的肠粘膜炎提供潜在的治疗益处.
- 对饮食和营养的进一步调查对于开发基于证据的策略来保护癌症患者至关重要.
- 了解作用机制,可以改善接受化疗的癌症患者的支持性护理.
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