自然产品对黑色素瘤血管生成的影响
Xurui Wang1, E Liu2, Changcheng Hou3
1Department of Chinese Medicine Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China,Chengdu, China; Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Fitoterapia
|July 7, 2024
概括
天然产品在抑制黑色素瘤血管生成方面表现有前途,这是皮肤癌生长的关键过程. 本次审查强调了27种化合物和15种提取物,这些化合物和提取物具有潜在的治疗机制,用于治疗黑色素瘤.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 自然产品化学 自然产品化学
背景情况:
- 黑色素瘤是最具攻击性的皮肤癌,由黑色素细胞的基因突变引起,主要是由紫外线辐射暴露引起的.
- 传统的黑色素瘤化疗显示出有限的疗效,引发了对基于天然产品的疗法的兴趣.
- 黑色素瘤血管生成对于瘤生长和转移至关重要,是重要的治疗点.
研究的目的:
- 审查和综合现有的关于天然产品抑制黑色素瘤血管生成的文献.
- 确定通过自然产品影响黑色素瘤血管生成的潜在机制.
- 探索自然产品在黑色素瘤临床前和临床环境中的治疗潜力.
主要方法:
- 在主要的科学数据库 (PubMed,EMBASE,科学网,奥维德,ScienceDirect,CNKI) 进行全面的文献搜索.
- 对研究天然产品及其对黑色素瘤血管生成的影响进行系统审查和分析.
- 基于其化学结构的自然产品的识别和分类 (类,多,类,黄类,类固醇).
主要成果:
- 27种不同的天然产品被确定为黑色素瘤血管生成的有效抑制剂.
- 十五种原油提取物是有前途的,尽管它们的活性成分需要进一步研究.
- 自然产品向关键途径,包括氧化应激,免疫炎症反应,细胞增殖和毛细血管形成.
结论:
- 自然产品提供了一种可行的策略,通过各种机制抑制黑色素瘤血管生成.
- 已识别的天然产品及其向物 (例如VE-cadherin,COX-2,VEGF) 为药物开发提供了基础.
- 对这些天然产品的进一步研究可以加速新型黑色素瘤治疗药物的开发.
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