在急性缺血性中风中检测长期和重复的微栓塞 - 挪威微栓塞在急性中风研究 (NOR-MASS) 中
Sander Johan Aarli1, Lars Thomassen1, Nicola Logallo2
1Department of Neurology, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway.
概括
在24小时内急性缺血性中风中,微栓塞信号很常见. 然而,延长和重复的监测并没有显著增加患者中这些信号的检测.
科学领域:
- 神经学 神经学
- 心血管医学 心血管医学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 使用跨皮多普勒监测 (TCDM) 检测大脑微栓塞有助于了解中风的原因和复发风险.
- 标准的TCDM监测持续时间可能会因为时间变化而忽略微血栓化.
- 评估长期和重复的TCDM对于优化微栓塞检测至关重要.
研究的目的:
- 为了评估急性缺血性中风患者微栓塞的时间进程.
- 确定长期和重复的微栓塞检测在增加诊断产量的有用性.
- 探索微栓塞发生与临床结果或中风复发之间的关联.
主要方法:
- 怀疑患有缺血性中风的患者接受了静止TCDM1小时,随后进行了门诊TCDM2小时.
- 单边的TCDM在接下来的两天和三个月的随访中被重复.
- 分析了47名患者的数据,包括患有缺血性中风,过渡性缺血性发作和黄病的患者.
主要成果:
- 在60%的患者中检测到微栓塞,最高发生在中风发作后24小时内.
- 经过长期和反复的监测,只发现了一名额外的微血栓阳性患者.
- 微栓塞发生与临床结果或中风复发之间没有发现显著的关联.
结论:
- 在急性缺血性中风的早期阶段,微栓塞信号很常见.
- 扩展和重复的TCDM监测并不能大大提高微栓塞的检测率.
- 早期对微栓塞的负面发现倾向于在整个监测过程中持续存在.
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