肠道微生物组与大脑功能变化之间的关系,在第一阶段,以前没有服用过药物的患有严重抑郁症的患者中

相关实验视频

Updated: Jun 21, 2025

07:49

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice

Published on: June 2, 2022

3.2K

Dahai Wang¹, Xiaowei Jiang², Huaqian Zhu³

¹Department of Psychiatry, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, PR China.

Journal of affective disorders

|July 7, 2024

概括

特定的肠道细菌如Blautia和Oxalobacteraceae与主要抑郁症 (MDD) 症状和大脑活动有关. 这些发现突出了微生物群-肠-大脑轴.

科学领域:

神经科学是一个神经科学.
微生物学微生物学
精神病学是一个精神病学.

背景情况:

微生物群-肠-大脑 (MGB) 轴越来越多地与主要抑郁症 (MDD) 病原发生有关.
肠道微生物组组成和MDD中大脑功能之间的确切关系尚不清楚.

研究的目的:

为了确定肠道微生物组和大脑功能的特定变化,在第一集,药物素朴的MDD患者.
探索肠道微生物组变化与MDD中大脑活动之间的关联.

主要方法:

16S rRNA基因测序用于便微生物组分析.
区域同质性 (ReHo) 来评估神经自发活动.
斯皮尔曼相关性将38名MDD患者和37名健康对照者的微生物组和大脑功能数据联系起来.

主要成果:

与对照组相比,MDD患者表现出明显的肠道微生物群概况和增加的额头ReHo.
蓝斑的丰度与抑郁症严重程度 (HAMD-17,HAMA评分) 有积极的相关性.
牛菌群的丰富度与HAMD-17分数呈正相关,而Porphyromonadaceae和Parabacteroides的丰富度与正面ReHo.有负相关.

结论:

特定的肠道细菌与MDD的前脑功能和临床症状有关.
这些发现支持微生物群-肠-大脑轴在MDD病理生理学的作用.
限制包括横截面设计和小样本大小.

关键词:

我们的肠道微生物组.大型抑郁症主要是抑郁症.微生物群-肠道-大脑 (MGB) 轴区域均性区域均性 rs-fMRI 是一个

相关概念视频

01:18

Depression: Overview

237

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...

237

01:23

Antidepressant Drugs: MAOIs and Other Agents

215

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...

215

01:17

Irritable Bowel Syndrome I: Introduction

265

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...

265

01:25

Antidepressant Drugs: Overview

430

Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...

430

01:30

Stress and Mental Health

Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...

01:23

Anatomy of the Intestines

71.7K

Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...