认知功能的损伤增加了死亡风险与心脏交感性缩和脏功能障碍在患有系统性心力衰竭的患者
Mirei Nabuchi1, Takahiro Doi1, Ryosuke Hatano1
1Department of Cardiology, Teine Keijinkai Hospita.
概括
认知障碍,心脏交感功能减弱和功能不良独立地预测心力衰竭 (HF) 患者的心脏事件. 这些因素协同增加HF患者的死亡风险.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 建立了心脏和脏相互作用的预后意义.
- 认知障碍对心脏预后的影响,特别是对心脏交感内置和心力衰竭 (HF) 患者的功能的影响,仍然不清楚.
研究的目的:
- 研究认知功能,心交感内置和功能对心力衰竭患者心脏预后的独立和联合影响.
主要方法:
- 433名高压患者 (LVEF <50%) 接受了认知查 (迷你精神状态检查 (MMSE) 和神经心理测试).
- 心脏交感内置被评估使用metaliodobenzylguanidine (MIBG) 剪影 (标准化心脏与中介质的比率[sHMR]).
- 通过估计的淋巴细胞过率 (eGFR) 评估功能;致命的心脏事件 (CEs) 被跟踪了14.8个月.
主要成果:
- 在84名患者中发生了CE.
- 患有CE的患者的MMSE得分,eGFR和sHMR都明显较低.
- 多变量分析确定了MMSE得分,eGFR和sHMR作为CE的独立预测因素.
- 在ROC分析中发现了CE风险增加的切线值 (MMSE <26,sHMR <1.80,eGFR <47.0 mL/min/1.73 m2).
结论:
- 认知功能受损是HF患者心脏病死亡率的独立预测因素.
- 认知障碍协同增加心脏死亡风险,与心脏交感功能和功能受损相结合.
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