在无症状高风险新生儿早期血糖查
Rania El-Khawam1, Vikramaditya Dumpa2, Shahidul Islam3
1Division of Neonatology, Department of Pediatrics, 24998 NYU Langone Hospital - Long Island, NYU Grossman Long Island School of Medicine , Mineola, NY, USA.
概括
对新生儿低血糖的早期查至关重要. 无症状的高风险新生儿,特别是那些晚期早产 (LPT) 或孕期大 (LGA) 的新生儿,在出生后的第一个小时内可能会出现严重的低血糖症.
科学领域:
- 新生儿医学 新生儿医学
- 儿科内分泌学 儿科内分泌学
- 临床新生儿学 临床新生儿学
背景情况:
- 及时检测和管理严重的新生儿低血糖症对于预防不良的神经发育结果至关重要.
- 对无症状,高风险新生儿的最佳葡萄糖查时间仍未得到充分研究.
- 关键的风险因素包括晚期早产 (LPT),怀孕年龄小 (SGA),怀孕年龄大 (LGA) 和糖尿病母亲的婴儿 (IDM).
研究的目的:
- 为了确定无症状,高风险新生儿早期低血糖的发生率.
- 评估个体风险因素对新生儿早期低血糖的影响.
- 为了确定与低血糖症相关的特定风险因素,在生命的第一个小时.
主要方法:
- 对1690名无症状高风险新生儿 (怀孕≥35周) 进行了回顾性分析.
- 早期血糖查在出生后的第一小时内对所有新生儿进行,包括新生儿.
- 该研究评估了低血糖危险因素与新生儿早期低血糖发病率之间的关联.
主要成果:
- 血糖≤25 mg/dL的发生率为3.1%,≤15 mg/dL的发生率为0.89%.
- 关于0.5%的无症状,有风险的新生儿的血糖≤10 mg/dL.
- 晚期早产 (LPT) 和大代孕年龄 (LGA) 与早期新生儿低血糖症有显著关联.
结论:
- 无症状的新生儿,特别是那些患有LPT或LGA的新生儿,在生命的第一个小时内容易发生严重的低血糖症.
- 早期血糖查对于识别有风险的婴儿至关重要.
- 需要进一步的研究来建立这些新生儿的最佳查和管理协议.
相关概念视频
01:22Diabetes Mellitus: Type 2 and Gestational
2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
01:15Diabetes: Symptoms, Diagnosis, and Complications
521
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
521
01:20Pathophysiology of Diabetes
917
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
917
01:27Glucose Transporters
22.6K
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
22.6K
01:15Hypoglycemia and Glucagon
254
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
254