绿色状因数设计优化了第一个衍生同步光谱法,用于在药物凝中测定三胺和二胺
Mona M Amer1, Basma Z El-Khateeb1
1Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Tanta University, The Medical Campus of Tanta University, Tanta, Egypt.
概括
一种新的绿色光谱法允许同时分析三氨酸化物和二氨酸. 这种环保的方法准确地量化这些药物在药物配方中使用细胞增强和衍生谱学.
科学领域:
- 分析化学 分析化学
- 绿色化学 绿色化学
背景情况:
- 同时确定三胺和二胺等制药化合物,由于光谱重叠,会带来分析挑战.
- 现有的方法可能缺乏环境可持续性或复杂配方的效率.
研究的目的:
- 开发和验证一种绿色的,微粒同步的光谱计法,用于同时量化三胺和二胺.
- 评估开发的分析方法的环保性.
主要方法:
- 使用同步光谱法测量,波长差异 (Δλ) 为60nm.
- 同步光光谱的第一个导数被用来解决光谱重叠.
- 使用二硫酸盐 (SDS) 进行状增强和通过因数设计进行优化.
- 量化在特定波长 (375纳米的tripelennamine化,293纳米的二胺) 达到,对应于零交叉点.
主要成果:
- 该方法在0.2-4.5微克/毫升的tripelenamine化和0.2-5微克/毫升的diphenhydramine的范围显示了线性.
- 检测极限为0.211微克/毫升的三聚胺化物和0.159微克/毫升的二胺.
- 在实验室制备的凝中成功应用,平均回收率高 (100.59 ± 0.79%和98.99 ± 0.98%) 证实了方法的有效性.
- 该方法使用绿色评估工具被验证为环保.
结论:
- 开发的绿色微粒同步光谱测量方法是有效和可靠的,用于同时确定散装和制药配方中的tripelenamine化和diphenhydramine.
- 该方法的环保性和高精度使其成为制药质量控制中的宝贵分析工具.
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