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Updated: Jun 21, 2025

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结核细胞衍生细胞状态的单细胞分辨率特征与癌症结局的含义

Gabriela Rapozo Guimarães1, Giovanna Resk Maklouf1, Cristiane Esteves Teixeira1

  • 1Laboratory of Bioinformatics and Computational Biology, Division of Experimental and Translational Research, Brazilian National Cancer Institute (INCA), Rio de Janeiro, RJ, Brazil.

Nature communications
|July 7, 2024
PubMed
概括

瘤透性髓状细胞 (MDCs) 是癌症结局的关键. 这项研究绘制了29种MDC亚型,确定了5种独立的预后标志物,包括TREM2+和FOLR2+细胞,对癌症治疗策略至关重要.

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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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