对耐火性H. pylori感染的人类胃微生物分析
Xianfeng Huang1, Da-Ya Zhang1, Da Li1
1Graduate School, Hainan Medical University, Haikou, 571199, China.
Scientific reports
|July 7, 2024
概括
杆菌 (H. pylori) 感染显著改变胃微生物群. 耐火性感染显示出明显的微生物变化,包括增加的Clostridium perfringens和Paracoccus marinus,以及减少的Vibrio shilonii.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 人类微生物组 人类微生物组
背景情况:
- 杆菌 (H. pylori) 感染是全球普遍存在的健康问题.
- 感染H. pylori对胃微生物群的影响尚未完全理解.
- 研究胃微生物的变化对于了解H. pylori的病变和治疗耐药性至关重要.
研究的目的:
- 研究初始和耐火H. pylori感染的患者胃微生物组合和功能的变化.
- 为了确定与H. pylori感染和根除失败相关的特定细菌物种和代谢途径.
- 在不同 H. pylori 感染状态下描述胃微生物景观.
主要方法:
- 从47个被分为H. pylori阳性 (HP),H. pylori阴性 (ck) 和耐火H. pylori (DiffHP) 组的个体收集了胃粘膜样本.
- 16S rDNA测序用于微生物社区分析.
- 使用PICRUSt.进行了微生物群落的功能预测.
主要成果:
- 在HP和ck组之间观察到胃菌群分布和功能的显著差异.
- 耐火性H. pylori感染 (DiffHP) 显示与HP组重叠的微生物特征.
- 特定的细菌丰度,包括Aeromonas,Shewanella,Vibrio,Microbacterium和Prevotella,在HP和DiffHP组相比ck显著减少.
- 在Clostridium perfringens和Paracoccus marinus中进行了丰富,而在DiffHP组中减少了Vibrio shilonii.
- 耐火性H. pylori感染与与人类疾病,有机系统和代谢过程相关的途径的丰富有关.
结论:
- 杆菌感染会导致胃微生物群的显著变化.
- 耐火性H. pylori感染表现出明显的微生物特征,其特点是Clostridium perfringens和Paracoccus marinus的增加和Vibrio shilonii的减少.
- 这些发现突显了胃微生物群改变在H. pylori根除失败中的潜在作用,并建议治疗干预的新途径.
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