Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Machines: Problem Solving I01:22

Machines: Problem Solving I

315
A toggle clamp is a mechanical device commonly used for holding and clamping objects in various applications, such as woodworking, metalworking, and assembly operations. Consider a toggle clamp subjected to a force of 200 N at the handle. The vertical clamping force can be calculated, provided the dimensions of the toggle clamp are known.
The toggle clamp system is a machine structure consisting of movable, pin-connected multi-force members that form a stabilized system to transmit forces. The...
315

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Evolution of resistance to KRAS<sup>G12C</sup> inhibitor in a non-small cell lung cancer responder.

Journal of genetics and genomics = Yi chuan xue bao·2026
Same author

Discovery of Novel Dual Small-Molecule Inhibitors Targeting SHP2 and NAMPT for Overcoming Resistance to Allosteric SHP2 Inhibition.

Journal of medicinal chemistry·2026
Same author

LRP4 is an entry receptor for multiple encephalitic alphaviruses.

Nature communications·2026
Same author

Activation of GABBR1 by New Ligand Valerate Transcriptionally Regulates ATF4-NRF2-CXCL13 Axis Mediating CD8<sup>+</sup> T Cell Anti-Tumor Immunity.

International journal of biological sciences·2026
Same author

Evaluating upper airway in orthodontics via 3D UX-Net model on CBCT scans.

Clinical oral investigations·2026
Same author

Nanofiber-based protection of DNA for archival data storage via coaxial electrospinning and chitosan integration.

Nanotechnology·2026

相关实验视频

Updated: Jun 21, 2025

Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

7.1K

一个化学机械合的DNA原木,能够产生强大的压缩力.

Chun Xie1, Kuiting Chen1, Zhekun Chen1

  • 1School of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, China.

Small (Weinheim an der Bergstrasse, Germany)
|July 8, 2024
PubMed
概括

研究人员开发了一种新的DNA纳米结构,该纳米结构可通过使用间隔器稳定地产生大压缩力 (≈11.2 pN). 这使得合成纳米系统的分子机器进步.

关键词:
基因原始的DNA原始化压缩力是一个压缩力.形状的变化 形状的变化它们是间歇性干扰.单个分子力是单个分子力.

更多相关视频

Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

14.5K
Designing a Bio-responsive Robot from DNA Origami
13:32

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

22.3K

相关实验视频

Last Updated: Jun 21, 2025

Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

7.1K
Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

14.5K
Designing a Bio-responsive Robot from DNA Origami
13:32

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

22.3K

科学领域:

  • 纳米技术 纳米技术
  • 生物物理学的生物物理.
  • 合成生物学 合成生物学

背景情况:

  • 动态DNA纳米结构对于研究生物力学和创造人工纳米系统至关重要.
  • 现有的纳米设备往往会由于概率的杂交反应产生小的非决定性力 (≈0.4 pN).

研究的目的:

  • 开发一种DNA纳米结构,能够稳定地产生大单分子力.
  • 为纳米系统设计具有确定性和放大力生成的纳米设备.

主要方法:

  • 开发一个交叉器触发的动态DNA原木纳米结构.
  • 利用介质器和纳米结构之间的局部结合反应来产生集体力.
  • 在不同硬度的生物分子负载上测试纳米结构的压缩力 (3, 4 和 6 螺旋 DNA 捆).

主要成果:

  • 与现有方法相比,新型纳米结构稳定地产生了明显更大的压缩力 (≈11.2 pN).
  • 产生的力量足以有效地曲不同的生物分子负载,包括DNA捆.
  • 通过间调器结合证明了确定性和放大力产生.

结论:

  • 这种间歇器触发的DNA纳米结构为产生大分子力提供了强大而坚固的工具.
  • 开发的纳米设备推动了合成纳米系统中化学机械合分子机器的构建.
  • 为纳米尺度的精确机械控制提供了一个新的平台.