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在神经损伤后,明显的thalamo-subcortical电路是痛苦行为和类似抑郁症的行为的基础

Jie Deng¹, Li Chen¹, Cui-Cui Liu²

¹Department of Physiology and Pain Research Center, Neuroscience Program, Zhongshan School of Medicine, The Fifth Affiliated Hospital, Guangdong Province Key Laboratory of Brain Function and Disease, Sun Yat-Sen University, Guangzhou, 510080, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|July 8, 2024

概括

慢性疼痛和抑郁症往往并存,使治疗复杂化. 这项研究确定了副腹腔丘脑 (PVT) 中明显的丘脑电路,这些电路调解疼痛和类似抑郁症的行为,提供潜在的治疗点.

科学领域:

神经科学是一个神经科学.
行为科学行为科学
病理生理学病理生理学

背景情况:

慢性疼痛和抑郁症经常同时发生,使患者的结果恶化,并使治疗复杂化.
驱动这种共同疾病的潜在神经机制尚未完全理解.
识别涉及的特定大脑电路对于开发向疗法至关重要.

研究的目的:

阐明对腹腔下丘脑 (PVT) 中独特的神经电路机制,这些机制有助于慢性疼痛和抑郁症的并发症.
区分特定PVT子区域及其下游目标在调解疼痛和类似抑郁症的行为中的作用.

主要方法:

利用一种神经损伤 (SNI) 模型来诱导慢性疼痛和类似抑郁症的行为.
在后PVT (PVP^Glu) 中研究的质神经元投射到腹侧周水道灰色 (VLPAG^GABA).
检查了前PVT (PVA^Glu) 中的谷氨酸性神经元,这些神经元投射到D1/D2-正的神经元 (NAc^D1→D2).

主要成果:

发现PVP^Glu→VLPAG^GABA电路在并发症的背景下调解与疼痛相关的行为.
确定PVA^Glu→NAc^{D1→D2电路参与了类似抑郁症的行为.}
这些独特的甲状腺皮层路径在SNI之后差异调节疼痛和抑郁症表型.

结论:

这项研究揭示了PVT内部的两个不同的乳头-皮下电路,它们独立地控制疼痛和类似抑郁症的行为.
这些发现为慢性疼痛和抑郁症并发症的电路水平基础提供了关键的见解.
这些已识别的电路代表了预防和治疗并发性慢性疼痛和抑郁症的潜在新目标.

关键词:

慢性疼痛是一种慢性疼痛.伴随性疾病发生率.抑郁抑郁症抑郁症抑郁症是一种它的核心是accumbens的核心.副腹腔体 thalamus 前腹部前腹部在前腹部副腹腔体 thalamus 后部垂体垂体垂体腹侧侧周水管道灰色灰色

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