在乳腺癌中 HER2 低表达达达达共识的最佳实践:从执业病理学家当前的观点
Gary Tozbikian1, Marilyn M Bui2, David G Hicks3
1Department of Pathology, The Ohio State University, Columbus, OH, USA.
Histopathology
|July 8, 2024
概括
精确的人类表皮生长因子受体2 (HER2) 免疫组织化学 (IHC) 评分对于乳腺癌 (BC) 治疗至关重要. 该指南有助于病理学家识别HER2-低BC,为关键患者群体提供有针对性的治疗.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 生物标记分析 生物标记分析
背景情况:
- 人类表皮生长因子受体2 (HER2) 表达是乳腺癌 (BC) 的关键生物标志物.
- HER2阴性 (HER2-) BC通常表现出较低的HER2水平 (IHC 1+或IHC 2+/ISH-),代表了一个重要的治疗类别.
- 用一种新的HER2-定向抗体-药物合物进行向治疗,可用于HER2-低BC.
研究的目的:
- 提供最佳实践和指导,以便在乳腺癌 (BC) 的HER2免疫组织化学 (IHC) 评分方面达成共识.
- 解决IHC测试和HER2-低表达BC的评分方面的挑战.
- 确保精确识别表达低水平HER2的BCs,以进行最佳的治疗选择.
主要方法:
- 专家病理学家概述了在BC中HER2 IHC评分的最佳实践.
- 介绍了一种建议的算法,用于使用验证的IHC测试来评估HER2表达.
- 该指南包括2023年美国临床瘤学会和美国病理学家学院的指南更新.
主要成果:
- 该研究详细介绍了HER2 IHC检测BC的当前知识和挑战.
- 提供了最佳实践,以准确识别HER2-低BC.
- 包括具有挑战性的HER2 IHC染色病例的例子.
结论:
- 准确的HER2 IHC评分对于乳腺癌的最佳治疗选择至关重要.
- 对HER2蛋白表达及其临床相关性的认识指导了针对性的治疗决策.
- 本指南促进了在BC中进行一致和可靠的HER2生物标志物测试.
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