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Updated: Jun 21, 2025

Anti-Nuclear Antibody Screening Using HEp-2 Cells
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Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

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在Jo-1 B细胞表皮形状和抗合成酶综合征的临床特征之间的关系

Koichi Yamaguchi1, Qi Tang2, Joseph J LaConti3

  • 1Gunma University Graduate School of Medicine, Gunma, Japan and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

ACR open rheumatology
|July 8, 2024
PubMed
概括

抗基转移RNA合成酶 (Jo-1) 自体的特定模式与抗合成酶综合征的明显临床表现相关,突出显示了这种自身免疫性疾病的表位图的诊断潜力.

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Antigens Involved in Adaptive Immunity

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Cross-reactivity

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B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
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Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
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