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Updated: Jun 21, 2025

Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model
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在怀孕期间使用Labetalol剂量:PBPK/PD和CYP2C19多态性

Xiaomei I Liu1, Dionna J Green2, John van den Anker1

  • 1Division of Clinical Pharmacology, Children's National Hospital, Washington, DC, USA.

Journal of clinical pharmacology
|July 8, 2024
PubMed
概括

这项研究开发了一种基于生理学的labetalol的药理动力学模型,预测其在怀孕期间的影响. Labetalol暴露因CYP2C19基因型而异,但血压降低在所有基因型中保持一致.

关键词:
在CYP2C19的多态化中.在Labetalol中使用.药理动力学是药理动力学的一个方面.基于生理学的药理动力学.怀孕 怀孕 怀孕 怀孕 怀孕

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