患有多囊性卵巢综合征的妇女进行辅助怀孕时的普罗利达斯活性
Kadriye Erdoğan1, Emine Utlu Özen2, İnci Kahyaoğlu1
1Department of Obstetrics and Gynecology, Health Sciences University, Etlik Zübeyde Hanım Women's Health Training and Research Hospital, Ankara, Turkey.
概括
患有多囊性卵巢综合征 (PCOS) 的女性在血清和卵泡液中具有较低的益化酶活性,影响卵巢原. 这可能会导致无排卵并影响IVF/ICSI治疗期间的胚胎质量.
科学领域:
- 生物化学和分子生物学
- 生殖内分泌学 生殖内分泌学
- 妇科 妇科 妇科 妇科
背景情况:
- 化酶是一种关键的依赖的酶,用于原重塑和细胞外矩阵 (ECM) 恒温.
- 卵巢ECM的失调与多囊性卵巢综合征 (PCOS) 病理生理学有关.
- 卵巢原在卵泡发育过程中经历了显著的降解,受到淋巴激素的影响.
研究的目的:
- 为了研究和比较PCOS女性的血清和卵泡液 (FF) 益酶活性,与接受IVF/ICSI的正常卵巢功能女性相比.
- 在PCOS的背景下,探索益利达酶水平,卵巢参数和胚胎质量之间的关系.
主要方法:
- 展望研究包括44名接受IVF/ICSI的妇女,根据鹿特丹标准分为PCOS (n=20) 和对照 (n=24) 组.
- 用奇纳德试剂进行光谱测量分析,测量血清和FF中的益利达酶活性.
- 益化酶水平的比较和与临床参数的相关性,包括 total antral follicle count 和胚胎细胞质量评分 (BQS).
主要成果:
- 与对照组相比,在患有PCOS的女性中观察到血清和FF益利达酶水平显著降低 (p < 0.05).
- 在血清和FF益酶水平 (p <0.05) 之间,以及在益酶水平和BQS之间 (p <0.05) 发现了正相关性.
- 血清化酶水平与 total antral follicle count (p <0.05) 有负相关性,而PCOS患者的BQS则降低.
结论:
- 在PCOS患者中,血清和FF益酶活性降低表明卵巢和卵泡原蛋白降解受损.
- 这种酶缺乏可能会导致无排卵,并对患有PCOS的女性的卵巢功能产生负面影响.
- 较低的益化酶水平与较差的胚胎质量有关,突出显示了其在生殖结果中的潜在作用.
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