老年人的终身创伤暴露和关节炎
Kristen Nishimi1, Ruijia Chen, Gabriela Schmajuk
1From the San Francisco Veterans Affairs Health Care System (Nishimi, Schmajuk, Neylan, O'Donovan); Department of Psychiatry and Behavioral Sciences, University of California San Francisco (Nishimi, Neylan, O'Donovan), San Francisco, California; Department of Epidemiology, Boston University School of Public Health (Chen), Boston, Massachusetts; and Departments of Medicine (Schmajuk) and Neurology (Neylan), University of California San Francisco, San Francisco, California.
童年创伤显著增加了晚年患关节炎的风险. 早期预防工作应将创伤暴露视为肌肉骨健康的关键因素.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 心理创伤学 心理创伤学
背景情况:
- 整个生命过程中的创伤事件与不良的身体健康结果有关.
- 现有的模型侧重于创伤总负担和关键暴露期.
- 关节炎是一种普遍的,具有多因素病因的衰弱性疾病.
研究的目的:
- 调查不同衡量人生创伤暴露和关节炎之间的关联.
- 为了区分任何创伤,创伤积累和暴露时间对关节炎风险的影响.
主要方法:
- 从健康和退休研究中对5717名参与者的分析.
- 作为任何创伤,积累和生命过程 (童年/成年) 资料,对终身创伤的建模.
- 使用回归和生存模型评估流行和发病关节炎.
主要成果:
- 任何终身创伤暴露与更高的患病率和发生性关节炎有关.
- 增加创伤积累显著预测了流行和发病关节炎.
- 儿童创伤暴露与关节炎有很强的关联,而成年暴露并不能预测事件病例.
结论:
- 较高的终身创伤负担,特别是在童年,可能会增加对关节炎的易感性.
- 创伤暴露与免疫相关和骨关节炎有关.
- 确定创伤是危险因素对于终身肌肉骨健康干预至关重要.
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