内体积是由遗传学和早期生命暴露驱动的:SOL-INCA-MRI研究
Tamar Sofer1,2,3, Einat Granot-Hershkovitz1, Wassim Tarraf4
1Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Ethnicity & disease
|July 8, 2024
概括
在西班牙裔/拉丁裔成年人中,内体积 (ICV) 遗传率为19%. 早期生活因素,如移民和父母教育,显著影响大脑发育和ICV.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 内体积 (ICV) 是大脑发育的关键指标,与生命后期的认知功能有关.
- 了解影响ICV的因素对于公共卫生和认知衰老研究至关重要.
研究的目的:
- 在西班牙裔和拉丁裔成年人中量化ICV.
- 估计ICV遗传性及其遗传关联.
- 检查早期生活环境因素对ICV的影响.
主要方法:
- 分析了来自1781个与拉丁裔研究中的非相关个体的MRI数据 - 认知衰老的MRI研究 (SOL-INCA-MRI).
- 估计ICV遗传性的情况.
- 测试与遗传变异的关联以及遗传风险得分 (GRS).
- 环境因素的评估:出生时间,移民年龄和父母的教育.
主要成果:
- 估计ICV的遗传率为19%.
- 四种遗传变异和ICV-GRS与ICV有显著的关联.
- 11岁以上的移民与较小的ICV (-24cm3) 有关.
- 更高的家长教育与更高的ICV (+15.4cm3) 有关.
结论:
- 遗传因素在ICV中发挥作用,但环境影响也很重要.
- 早期生活条件,包括移民和父母教育,影响大脑发育.
- 这些发现强调了早期生命健康对认知衰老的重要性.
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