结核相关阻塞性肺病 (TOPD) 的新型炎症指标:全身炎症反应指数 (SIRI)
Shengling Hu1, Qi Yu1, Fenfang Liu1
1Department of Infectious Diseases, Wuhan Jinyintan Hospital, Tongji Medical College of Huazhong University of Science and Technology; Hubei Clinical Research Center for Infectious Diseases; Wuhan Research Center for Communicable Disease Diagnosis and Treatment, Chinese Academy of Medical Sciences; Joint Laboratory of Infectious Diseases and Health, Wuhan Institute of Virology and Wuhan Jinyintan Hospital, Chinese Academy of Sciences, Wuhan, 430023, People's Republic of China.
系统性炎症反应指数 (SIRI) 可以预测结核病患者的结核相关阻塞性肺病 (TOPD). 较高的SIRI水平表明患TOPD的风险增加,提供了潜在的查工具.
科学领域:
- 肺部医学 肺部医学
- 传染性疾病 传染性疾病
- 炎症研究 炎症研究
背景情况:
- 结核相关阻塞性肺病 (TOPD) 是结核后的一种严重并发症.
- 确定TOPD的预测标志物对于结核病幸存者的早期干预至关重要.
研究的目的:
- 评估有结核病史的患者TOPD炎症指标的预测价值.
- 评估系统性炎症反应指数 (SIRI) 与发展TOPD的风险之间的关联.
主要方法:
- 一项涉及737名结核病患者的横截面研究.
- 计算和分析炎症指数,包括SIRI,CLR和ELR.
- 使用了后勤回归,倾向得分匹配 (PSM) 和ROC曲线分析.
主要成果:
- 共有83名患者 (11.26%) 被诊断患有TOPD.
- SIRI独立地与 TOPD 的风险增加有关 (PSM 之前的 AUC 0.702,PSM 后的 0.668).
- 随着SIRI四分位数的增加,TOPD的患病率增加,这表明了剂量-反应关系.
结论:
- 在TOPD患者中观察到炎症标志物,特别是SIRI的升高.
- SIRI作为一个简单而有效的炎症指数,用于评估TOPD风险.
- 结核病患者具有较高的SIRI值代表 TOPD 发展的高风险群体.
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