拜托温格可以通过通过DOPA脱酶促进调节型结肠炎来缓解性结肠炎
Junzhi Zhang1, Binyan Lin2, Ying Zhang1
1The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, China.
Frontiers in pharmacology
|July 8, 2024
概括
拜托温格 (BTW) 通过调节甲酸代谢并增强肠道屏障功能,有效治疗小鼠的性结肠炎. 它促进了醇代谢物,并激活了烯碳化合物受体 (AHR) /IL-22通路,以获得治疗效益.
科学领域:
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- (BTW) 是一种传统的中国植物配方,用于治疗肠道疾病.
- 它在治疗性结肠炎 (UC) 的有效性需要进一步研究.
研究的目的:
- 评估BTW对小鼠中酸 (DSS) 诱导的大肠炎的治疗效果.
- 阐明底层的作用机制,包括其对托代谢和肠道屏障功能的影响.
主要方法:
- 在小鼠中使用DSS诱导实验性结肠炎,并用BTW,kynurenine或carbidopa治疗.
- 在体外研究中,参与了用BTW或carbidopa治疗的TNF-α刺激的Caco-2细胞.
- 分析包括疾病活性指数,结肠长度,组织病理学,细胞因子水平,蛋白质组,托代谢物 (LC-MS/MS),以及肠道屏障标记物 (IHC,西部斑).
主要成果:
- BTW显著降低了疾病活动指数和结肠损伤,同时调节了炎症性细胞因子.
- 该配方通过上调紧密结合蛋白来增强肠道上皮质屏障的修复.
- BTW通过降低kynurenine和增加醇代谢物,促进DOPA脱碳酶 (DDC) 表达和激活酸受体 (AHR) /IL-22通路来调节酸代谢.
结论:
- 拜图文可以改善性结肠炎,通过促进DDC的表达和将托代谢转移到醇代谢产物.
- 通过激活AHR受体,BTW可以恢复肠道屏障功能.
- 这些机制共同有助于BTW在性结肠炎的治疗疗效.
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