Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

295
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
295
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

3.8K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
3.8K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Population Pharmacokinetics of Intravenous Colistin Sulfate in Critically Ill Patients with Pneumonia.

Infection and drug resistance·2026
Same author

An Injectable "Gas-Electro" Bionic Hydrogel for Spatiotemporal Monitoring and Repair of Myocardial Infarction via Sustained H<sub>2</sub>S Release and Electrophysiological Repair.

ACS applied materials & interfaces·2026
Same author

Repeated tDCS of the left dorsolateral prefrontal cortex for acute DoC: a pilot randomized controlled trial.

Scientific reports·2026
Same author

Coordination-driven self-assembled nanozyme-loaded GelMA microneedles for enhanced photodynamic therapy of diabetic infected wounds.

Journal of materials chemistry. B·2026
Same author

A single-component photo-crosslinked chitosan hydrogel with inherent antimicrobial and antioxidant capabilities for wound healing.

Journal of materials chemistry. B·2026
Same author

Design of High-Efficiency Composite Sound-Absorbing Fabric via Hollow Fiber Membrane Weaving Technology.

Langmuir : the ACS journal of surfaces and colloids·2026

相关实验视频

Updated: Jun 21, 2025

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method
12:03

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

Published on: April 18, 2019

26.1K

聚密辛:最近的进展和挑战

Shan Yang1, Hairui Wang2, Dan Zhao1

  • 1Department of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China.

Frontiers in pharmacology
|July 8, 2024
PubMed
概括

聚米克辛是对抗多药耐药性格拉姆阴性感染的至关重要的最后手段抗生素. 本审查审查了它们的机制,耐药性和药理动力学,以指导未来的抗菌药物开发.

科学领域:

  • 微生物学 微生物学
  • 药理学 药理学是指药理学的学科.
  • 传染性疾病 传染性疾病

背景情况:

  • 抗生素耐药性对全球健康构成重大威胁.
  • 聚米克辛,特别是素,是对抗多药性格拉姆阴性感染的至关重要的最后手段.
  • 了解多素耐药机制和药理学对于持续的疗效至关重要.

研究的目的:

  • 审查聚胺抗菌机制和耐药性途径.
  • 探索克服多素耐药性的创新策略.
  • 为了研究多素的药理动力学和影响体内行为的因素.

主要方法:

  • 对目前关于多基因的研究进行文献综述.
  • 对抗菌机制和耐药性途径的分析.
  • 检查药物动力学数据和体内研究.

主要成果:

  • 聚米克辛表现出复杂的抵抗机制.
  • 目前正在开发各种策略来对抗多素耐药性.
  • 药物动力学变异性会影响多素的疗效和毒性.

结论:

关键词:
抗菌机制是一种抗菌机制.药物耐药性机制 抗药性机制纳米技术是纳米技术.药物动力学 药物动力学聚氨酸是多种类型的

更多相关视频

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
08:08

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

22.0K
Generating Transposon Insertion Libraries in Gram-Negative Bacteria for High-Throughput Sequencing
08:19

Generating Transposon Insertion Libraries in Gram-Negative Bacteria for High-Throughput Sequencing

Published on: July 7, 2020

10.3K

相关实验视频

Last Updated: Jun 21, 2025

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method
12:03

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

Published on: April 18, 2019

26.1K
Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
08:08

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

22.0K
Generating Transposon Insertion Libraries in Gram-Negative Bacteria for High-Throughput Sequencing
08:19

Generating Transposon Insertion Libraries in Gram-Negative Bacteria for High-Throughput Sequencing

Published on: July 7, 2020

10.3K
  • 对于对抗耐药性细菌感染,全面了解多素是必不可少的.
  • 需要进一步的研究来优化多素的使用和开发新的药物.
  • 推进多菌素研究对于应对未来的抗微生物挑战至关重要.