通过系统的字母数字编码内镜在上消化器内镜中使用N-乙半氨酸加simethicone来改善粘膜可见性:一个随机的,双盲控制试验
Sergio Sobrino-Cossío1, Fabian Emura2, Oscar Teramoto-Matsubara3
1Hospital Angeles del Pedregal, Gástrica, Centro Avanzado en Endoscopia y Estudios Funcionales, Mexico city, México (Sergio Sobrino-Cossío).
结合N-乙半氨酸和simethicone显著改善上部胃肠道 (GI) 内镜粘膜的可见性. 这种增强的可视化可能会在手术过程中更好地检测病变.
科学领域:
- 胃肠病学 胃肠病学
- 内镜成像系统的成像
- 药理学 药理学是指药理学的学科.
背景情况:
- 在上部胃肠道 (GI) 内镜中优化病变检测需要有效的抗泡和粘菌剂.
- 充分的粘膜可见性 (AMV) 对于成功的内镜检查至关重要.
研究的目的:
- 评估在上部肠道内镜检查期间,西美西康和N-乙半氨酸对AMV的影响.
- 以系统的方式比较这些药物的有效性,单独和组合.
主要方法:
- 一个随机的,双盲的受控试验,涉及4564个上部肠道图像.
- 患者被分配到四个组:水,仅使用西米西康,N-乙西 + 西米西康,或仅使用N-乙西.
- 评估包括AMV,副作用和其他患者参数.
主要成果:
- 结合N-乙半氨酸和simethicone,显示出更高的清洗百分比 (P=0.001).
- 所有组的平均AMV为93.98±7.36%.
- 其他组之间没有观察到显著差异,尽管单个药物显示了一些改善.
结论:
- 结合N-乙半氨酸和simethicone是有效的优化上部GI粘膜的可见性.
- 改善可见性有可能提高上部肠道内镜的诊断产量.
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