菌 (candida albicans) 是否可能成为自闭症的危险因素? 一个元分析研究研究
Emrah Gokay Ozgur1, Sibel Balci2
1Marmara University, School of Medicine, Department of Biostatistics, Istanbul, Turkey.
African health sciences
|July 8, 2024
概括
患有自闭症谱系障碍的儿童表现出更高的Candida albicans存在. 这种真菌可能是自闭症行为的病因因素,因此需要进一步调查这种潜在的自闭症风险因素.
科学领域:
- 医学研究 医学研究
- 微生物学 微生物学
- 神经科学是一个神经科学.
背景情况:
- 在全球范围内,自闭症谱系障碍 (ASD) 的发生率正在增加.
- 了解自闭症病因对于有效的干预至关重要.
- 微生物因素在ASD中的潜在作用是一个新兴的研究领域.
研究的目的:
- 调查Candida albicans和自闭症谱系障碍之间的关联.
- 评估Candida albicans作为自闭症行为的潜在风险因素.
主要方法:
- 在主要数据库 (Scopus,PubMed,Web of Science,PsycINFO) 进行了系统的文献搜索,截至2021年12月.
- 进行了4项研究的元分析,其中包括254名患有自闭症儿童和161名健康对照.
- 使用固定效应和随机效应模型计算了几率比率,评估了异质性和出版偏差.
主要成果:
- 与健康对照组相比,被诊断患有自闭症谱系障碍的儿童表现出Candida albicans存在的几率明显更高 (OR=7.21;95% CI:3.75-13.85;p<0.001).
- 分析显示,Candida albicans和ASD之间存在强烈的统计关联.
- 对异质性和出版偏差进行了统计评估.
结论:
- 患有自闭症谱系障碍的儿童表现出更高频率的Candida albicans感染.
- 虫 Candida albicans 可能是导致自闭症行为的一个病因因素.
- 需要进一步的研究来证实因果关系并探索治疗意义.
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