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在SARS-CoV-2感染中白细胞的形态异常

Moueden Amine¹, Messaoudi Reda¹, Derouiche Mokhtar¹

¹Université d'Oran 1 Ahmed Ben Bella Faculté de Médecine, Pharmacie.

African health sciences

|July 8, 2024

概括

严重急性呼吸系统综合征冠状病毒-2 (SARS-CoV-2) 感染在COVID-19患者中引起显著的白细胞形态异常. 这些包括中性粒细胞,淋巴细胞和单细胞的变化,有毒颗粒是特定的发现.

科学领域:

血液学血液学血液学
传染性疾病传染性疾病
病毒学病毒学

背景情况:

冠状病毒疾病2019 (COVID-19) 是由严重急性呼吸系统综合征冠状病毒-2 (SARS-CoV-2) 病毒引起的.
SARS-CoV-2 影响血液细胞的分化和成熟.
在COVID-19期间白细胞形态需要详细调查.

研究的目的:

调查和记录COVID-19患者白细胞的形态异常.
量化感染期间观察到的特定白细胞变化.

主要方法:

在5个月内 (2021年2月 - 2021年6月) 进行的前性研究.
包括40名COVID-19患者和20名健康对照.
进行完整血清和外围血液涂抹分析,量化白细胞异常.

主要成果:

在中性粒细胞中观察到显著的形态异常,包括双叶形状 (72.5%),低粒度 (45%) 和真空化 (42.5%).
经常发现不典型的淋巴细胞 (52.5%) 和淋巴质细胞 (60%).
具体发现包括获得的伪Pelger-Huet异常 (35%) 和骨髓细胞中有毒颗粒 (30%).

结论:

COVID-19与不同细胞系的白细胞形态异常有关.
骨髓细胞中有毒颗粒的存在是本研究中发现的独特特征.

关键词:

在 COVID-19 疫情中,这些异常是异常.淋巴细胞淋巴细胞.一个单细胞单细胞.作为一个中性恋者.周围血液涂抹检查

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